منابع مشابه
Toll-like receptors and renal disease.
Toll-like receptors (TLRs) play a central role in the response of both the innate and the adaptive immune system to microbial ligands. There is also evidence that they are stimulated by endogenous ligands. In this review, I discuss evidence that they are important in renal disease. This discussion considers the role of both endogenous and microbial ligands, and also the contribution of TLRs pre...
متن کاملToll-like receptors and renal bacterial infections.
Urinary tract infection and pyelonephritis are mainly due to uropathogenic Escherichia coli (UPEC), and are common infectious diseases that constitute a significant cause of morbidity and mortality in humans. They are also the most frequent infectious complications in renal transplant patients, and can impair long-term renal graft function and outcome. UPEC may invade the kidneys via the system...
متن کاملI-23: Reproduction and Toll Like Receptors(TLRs
Female and male reproductive tracts are of interest sites to study of immune system because they encounter specific infections such as those are sexually transmitted. Furthermore, female reproductive tract is in close contact with allogenic sperms and transmitted microorganisms during intercourse and semi allogenic fetus during pregnancy. In mammals, there are two types of immune responses, the...
متن کاملToll-like receptors and chronic lung disease.
TLRs (Toll-like receptors) comprise a family of proteins whose function is principally to facilitate the detection of, and response to, pathogens. Protozoa, helminths, viruses, bacteria and fungi can all activate TLR signalling, and these signals have important roles in the activation of host defence. TLRs may also respond to products of tissue damage, providing them with roles in infective and...
متن کاملToll-like Receptors and Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is one relapsing and lifelong disease that affects millions of patients worldwide. Increasing evidence has recently highlighted immune-system dysfunction, especially toll-like receptors (TLRs)-mediated innate immune dysfunction, as central players in the pathogenesis of IBD. TLRs and TLR-activated signaling pathways are involved not only in the pathogenesis but ...
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ژورنال
عنوان ژورنال: Nephron Experimental Nephrology
سال: 2009
ISSN: 1660-2129,1660-2129
DOI: 10.1159/000228077